中文名称

I-RTX；4-羟基-3-碘-5-甲氧基-[（2S，6aR，10R，11aR）-3aR，3bS，6,6a，9aR，10,11,11a-八氢-6a-羟基-8,10-二甲基-11a-（1-甲基乙烯基）-7-氧-2-（苯基甲基）-7H-2,9bR-环氧azuleno [5,4-e] -1,3-苯并二恶唑-5-基]甲酯

英文名字

I-RTX; 4-hydroxy-3-iodo-5-methoxy-[(2S,6aR,10R,11aR)-3aR,3bS,6,6a,9aR,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9bR-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester

供应商

Cayman Chemical

产品货号

15367-1

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

Resiniferatoxin (Item No. 11349) is a natural analog of capsaicin (Item No. 92350) that activates the transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1.{24790} 5'-Iodoresinferatoxin (I-RTX) is a potent and reversible antagonist of TrpV1 (Kd = 4.3 nM).{24900} However, it can also act as a partial TRPV1 agonist at higher concentrations in vitro, inducing a biphasic response with EC50 values of 56.7 nM and 9.9 μM.{24899} I-RTX blocks activation of TRPV1 by capsaicin both in vitro and in vivo.{24900,24901,24896} It also blocks neurogenic pain induced by inflammatory mediators.{24897,24898}

产品描述

A potent and reversible antagonist of TRPV1 (Kd = 4.3 nM); can also act as a partial TRPV1 agonist at higher concentrations in vitro, inducing a biphasic response with EC50 values of 56.7 nM and 9.9 μM; blocks activation of TRPV1 by capsaicin and pain induced by inflammatory mediators

产品形式

A white to off-white solid

保存建议

建议您在收到Cayman Chemical品牌的5'-Iodoresiniferatoxin (1 mg)产品后置于-20度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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