- 中文名称
重组人ECT2 BRCT结构域（25ug）
- 英文名字
- ECT2 BRCT domains (human recombinant)
- 供应商
- Cayman Chemical
- 产品货号
- 14168-25
- 产品报价
- ￥已停产
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP from small GTPases of the Rho family, such as RhoA, RhoC, Rac1, and Cdc42.{24795} ECT2 GEF activity plays an essential role during cytokinesis.{24792} ECT2 contains a DH (DBL-homology) domain, a pleckstrin homology (PH) domain and tandem BRCT domains.{24794} BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions.{23632,22097} BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein and the yeast cell cycle checkpoint protein RAD9.{23633} BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse.{22097} Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both.{23634,23633} The BRCT domains of ECT2 make intramolecular interactions with the C-terminal DH/PH domains of the protein, thus, masking the catalytic GEF activity for Rho GTPases.{24796} Additionally, release of the autoinhibition by the BRCT domains may be necessary for the proper functioning of ECT2 during cytokinesis.{24796} Expression levels of ECT have been shown to be strongly correlated with prognosis in glioma patients.{24793}
- 产品描述
- 提供的重组人ECT2 BRCT结构域（25ug）产品形式为：50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
- 产品形式
- Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP from small GTPases of the Rho family, such as RhoA, RhoC, Rac1, and Cdc42.{24795} ECT2 GEF activity plays an essential role during cytokinesis.{24792} ECT2 contains a DH (DBL-homology) domain, a pleckstrin homology (PH) domain and tandem BRCT domains.{24794} BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions.{23632,22097} BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein and the yeast cell cycle checkpoint protein RAD9.{23633} BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse.{22097} Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both.{23634,23633} The BRCT domains of ECT2 make intramolecular interactions with the C-terminal DH/PH domains of the protein, thus, masking the catalytic GEF activity for Rho GTPases.{24796} Additionally, release of the autoinhibition by the BRCT domains may be necessary for the proper functioning of ECT2 during cytokinesis.{24796} Expression levels of ECT have been shown to be strongly correlated with prognosis in glioma patients.{24793}
- 保存建议
- 建议您在收到Cayman Chemical品牌的重组人ECT2 BRCT结构域（25ug）产品后置于-80度保存，产品有效期为365天.
- 其他
- Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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