中文名称

重组人复制起始识别复合体ORC-1 BAH结构域（25ug）

英文名字

ORC1 BAH domain (human recombinant)

供应商

Cayman Chemical

产品货号

11919-25

产品报价

￥已停产

产品说明书

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购买方式

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产品新闻

背景资料

ORC1, a component of the Origin Recognition Complex, is necessary for the initiation of DNA replication. It is bound in complex with ORC2, ORC3, ORC4, ORC5, and ORC6. The BromoAdjacent Homology (BAH) domain of ORC1 recognizes histone 4 dimethylated at lysine 20, which is enriched at replication origins (ORI).{21060} Chromatin immunoprecipitation and parallel sequencing of ORC1 DNA binding sites has been used to identify the ORI sites in HeLa cells.{25191} In addition to BAH mediated nucleosome recognition, ORC1 contains ATPase activity which is required for loading the minichromosome maintenance helicase complex.{25192} ORC1 levels oscillate during the cell cycle, decreasing during S phase following formation of pre-replication complexes.{25194} Mutations in ORC1 have been shown to cause Meier-Gorlin syndrome, a form of primordial dwarfism.{25193} This protein product contains the BAH domain region of ORC1.

产品描述

提供的重组人复制起始识别复合体ORC-1 BAH结构域（25ug）产品形式为：20 mM Tris, pH 8.0, containing 50 mM sodium chloride and 20% glycerol.

产品形式

ORC1, a component of the Origin Recognition Complex, is necessary for the initiation of DNA replication. It is bound in complex with ORC2, ORC3, ORC4, ORC5, and ORC6. The BromoAdjacent Homology (BAH) domain of ORC1 recognizes histone 4 dimethylated at lysine 20, which is enriched at replication origins (ORI).{21060} Chromatin immunoprecipitation and parallel sequencing of ORC1 DNA binding sites has been used to identify the ORI sites in HeLa cells.{25191} In addition to BAH mediated nucleosome recognition, ORC1 contains ATPase activity which is required for loading the minichromosome maintenance helicase complex.{25192} ORC1 levels oscillate during the cell cycle, decreasing during S phase following formation of pre-replication complexes.{25194} Mutations in ORC1 have been shown to cause Meier-Gorlin syndrome, a form of primordial dwarfism.{25193} This protein product contains the BAH domain region of ORC1.

保存建议

建议您在收到Cayman Chemical品牌的重组人复制起始识别复合体ORC-1 BAH结构域（25ug）产品后置于-80度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

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