中文名称

N- [4- [5-（1,3-3-苯并二恶唑-5-基）-3-甲氧基-1H-1,2,4-三唑- 1- [基]苯基] -2-（苯硫基）乙酰胺

英文名字

N-​[4-​[5-​(1,​3-​benzodioxol-​5-​yl)​-​3-​methoxy-​1H-​1,​2,​4-​triazol-​1-​yl]​phenyl]​-​2-​(phenylthio)​-acetamide

供应商

Cayman Chemical

产品货号

10009570-25

产品报价

￥询价/25mg

产品说明书

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购买方式

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产品新闻

背景资料

Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways.{25737} SecinH3 is a selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM.{14565} It binds the Sec7 domain of these small Arf-GEFs but does not bind Sec7 domains of larger Arf-GEFs.{25739} In human liver carcinoma HepG2 cells, SecinH3 prevents cytohesin-dependent insulin signaling.{14565} In mice, SecinH3 produces hepatic insulin resistance.{14565} Inhibition of the cytohesin GEF from Drosophila, Steppke, blocks insulin signaling and interferes with development.{25736} SecinH3 is useful for studying the diverse roles of cytohesins, including the regulation of receptor-mediated cancer cell proliferation.{25738}

产品描述

A selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM; prevents cytohesin-dependent insulin signaling in HepG2 cells; produces hepatic insulin resistance in mice

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的SecinH3 (25 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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