Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
序列
该Recombinant rat Cellular tumor antigen p53 protein的序列请参考该产品的说明书
来源宿主
该Recombinant rat Cellular tumor antigen p53 protein的来源宿主请参考该产品的说明书
溶解建议
该Recombinant rat Cellular tumor antigen p53 protein的溶解建议请参考该产品的说明书
保存建议
该Recombinant rat Cellular tumor antigen p53 protein的保存建议请参考该产品的说明书
其他
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