E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. collaborates with atxn3 in the degradation of misfolded chaperone substrates: atxn3 restricting the length of ubiquitin chain attached to stub1/chip substrates and preventing further chain extension. ubiquitinates nos1 in concert with hsp70 and hsp40. modulates the activity of several chaperone complexes, including hsp70, hsc70 and hsp90. mediates transfer of non-canonical short ubiquitin chains to hspa8 that have no effect on hspa8 degradation. mediates polyubiquitination of dna polymerase beta (polb) at 'lys-41', 'lys-61' and 'lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the huwe1/arf-bp1-dependent monoubiquitination and leading to polb-degradation by the proteasome. mediates polyubiquitination of cyp3a4. ubiquitinates epha2 and may regulate the receptor stability and activity through proteasomal degradation. negatively regulates the suppressive function of regulatory t-cells (treg) during inflammation by mediating the ubiquitination and degradation of foxp3 in a hspa1a/b-dependent manner (pubmed:23973223).
产品描述
该STUB1 ELISA Kit (Mouse)的产品描述请参考该产品的说明书
产品特点
ELISA试剂盒
保存建议
2°C to 8°C, -20°C
其他
Aviva Systems Biology总部位于加利福尼亚州圣迭戈，在中国北京设有办公室，专注于为研究需求提供多克隆和单克隆抗体、ELISA试剂盒、蛋白质和定制服务。Aviva Systems Biology生产了24,000种经过验证的多克隆抗体，并提供近20,000种ELISA试剂盒，定制实验室服务包括蛋白表达和纯化、抗体开发，以及ELISA的开发、验证和生产。Aviva Systems Biology为与独特物种和靶标相关的研究提供独特工具，研究领域包括转录因子、癌症、心血管、细胞生物学、DNA损伤和修复、表观遗传学、信号转导、细胞分化、干细胞生物学等等。
