Autophagy involves concerted action of more than 20 specific autophagy (ATG) proteins that mediate the formation of a double-membrane vesicle, the autophagosome, which engulfs its substrates and delivers them to the lysosome for degradation. In many cases control of substrate selectivity is mediated by ubiquitin modification.
Two ubiquitin-like protein conjugation systems regulate expansion. Atg8 is processed by the Atg4 protease at its C-terminus, activated by the E1-like enzyme Atg7 and conjugated to PE by the E2-like protein Atg3. Atg12
应用类型
免疫原
Peptide derived from C-terminal region of human Atg7 protein
