An agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Primary active component of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets. ER stress inducer.
Activates autophagy, a process by p38 and ERK at the sequestration and maturation steps respectively.