BAG1 and BAG3 are co-chaperone protein members of the Bcl-2-associated athanogene (BAG) protein family and have been shown to participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis.
Under physiological conditions Hsp70 mediated quality control of misfolded proteins is mainly achieved by BAG1-dependent proteasomal degradation of polyubiquitin modified proteins. During ageing or under conditions of acute stress, involving accumulation of misfolded and aggregated proteins, a switch in co-chaperone expression from BAG1 to BAG3 results in upregulation of autophagic degradation through targeting by the
应用类型
免疫原
N-terminal peptide derived from human BAG1 protein
