The class II histone deacetylase HDAC6 catalyzes the deacetylation of lysine residues on the N-terminus of core histones, playing a key role in epigenetic regulation of gene transcription. It has been identified as a cytoplasmic deacetylase that acts on tubulin and HSP90 to influence cell motility and is involved in stress response as a component of cytoplasmic stress granules.
In addition ubiquitin binding HDAC6 plays a central role in the selective targeting of protein aggregates and damaged mitochondria for destruction by autophagy, a process also known as aggrephagy. HDAC6 is not required for autophagy activation but controls the fusion of autophagosomes to lysosomes, its deficiency leading to autophagosome maturation failure, protein aggregate build-up, and neurodegeneration. It does not appear to play a role in starvation-induced autophagy.
应用类型
免疫原
C-terminal peptide derived from human HDAC6 protein
