Catenin B-1 also known as B-catenin is a protein that in humans is encoded by the CTNNB1 gene. B-catenin is the first characterized member of the B -catenin family. B-catenin contains 12 ARM repeats and has a dual function, depending on its localization. Cytoplasmic B-catenin is a critical component of E-cadherin/catenin adhesion complexes and regulates cadherin-dependent cell-cell interactions. When localized to the nucleus, B -catenin regulates binding to transcription factors from the TCF/LEF family, activating transcription. B -catenin is expressed in hair follicle cells such as those found in the inner and outer portions of the root sheaths, and the basal and peripheral matrix cells. Expression has also been observed in colon tissue. Defects in expression have been linked to the development of several tumors and cancers.
应用类型
WB
免疫原
人B-catenin 酪氨酸654磷酸化位置 (A-T-YP-A-A) 附近 (未磷酸化的).
来源宿主
兔
反应性
人 | 小鼠 | 大鼠
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍17674多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Strꮺ䈞ꡊ䈟厨䈠썪䈠䲺㓚坊䉥뀚䇭జ㑟뙪䱱ጞ䉈䉝롌⚙◢⌭䄠䇮軈㟀se
