Transforming growth factor B 1 or TGF-B1 is a polypeptide member of the transforming growth factor B superfamily of cytokines. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
应用类型
WB | IHC | ELISA
免疫原
人 TGF B1 合成肽
来源宿主
兔
反应性
人 | 小鼠 | 大鼠
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍17531多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Strꮺ䈞ꡊ䈟厨䈠썪䈠䲺㓚坊䉥뀚䇭జ㑟뙪䱱ጞ䉈䉝롌⚙◢⌭䄠䇮軈㟀se
