Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.
应用类型
WB
免疫原
合成肽 aa.291~295(G-G-R-D-S)
来源宿主
兔
反应性
人 | 小鼠 | 大鼠
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍17269多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Strꮺ䈞ꡊ䈟厨䈠썪䈠䲺㓚坊䉥뀚䇭జ㑟뙪䱱ጞ䉈䉝롌⚙◢⌭䄠䇮軈㟀se
