Interferon gamma (IFNy) is a dimerized soluble cytokine that is the only member of the type II class of interferons. It is an antiviral and antiparasitic agent produced by CD4+/CD8+ lymphocytes and natural killer cells that undergo activation by antigens, mitogens or alloantigens. IFN-gamma production modulates T cell growth and differentiation and inhibits the growth of B cells. Synthesis of IFN-gamma is inducible by IL-2, FGF and EGF. The active form of IFN-gamma is a homodimer with each subunit containing six helices. The dimeric structure of human IFN-gamma is stabilized by non-covalent interactions through the interface of the helices. IFN-gamma tranlsated precursor is 166 amino acids, including the 23 amino acid secretory sequence. 20 kDa and 25 kDa forms exist due to variable glycosylation; 40-60 kDa forms are observable under non-denaturing conditions as dimers and tetramers.
应用类型
WB | IHC
免疫原
人 Interferon gamma合成肽.
来源宿主
兔
反应性
人
保存建议
厂家推荐蓝冰运输。收到产品后建议保存于-20ºC。
其他
StressMarq Biosciences Inc. 在2007年成立于加拿大维多利亚，是一家生物科技公司，专门从事试剂与试剂盒研究，服务范围遍17194多个国家。 StressMarq公司的核心技术领域为细胞应激（尤其是热休克蛋白（HSP）领域，领先全球），离子通道，载体研究，同时在神经科学领域推出特有的具有生物活性的Tau蛋白与A-突触核蛋白。产品领域涉及到：细胞凋亡、细胞信号、通路和转运、细胞器标志物、热休克、神经生物学、神经科学、氧化应激、磷酸化运输等。除了提供用于进一步研究的相关工具外，Strꮺ䈞ꡊ䈟厨䈠썪䈠䲺㓚坊䉥뀚䇭జ㑟뙪䱱ጞ䉈䉝롌⚙◢⌭䄠䇮軈㟀se
