ARL11 （ADP-ribosylation factor-like protein 11） belongs to the ARF family of the Ras superfamily of small GTPases which are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins which enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they have a vital role in the activation of phospholipase D （PC-PLD）. ARL11 is assumed to act as a tumor suppressor which may have a role in the regulation of apoptosis.
