NR1H2 regulates the metabolism of cholesterol and bile acids. There are 2 subtypes of LXR， LXR-alpha & LXR-beta. NR1H2 is a ligand-dependent transcription factor that forms heterodimer with the retinoid X receptor. LXR- member of Nuclear Receptor Family is triggered by specific oxysterol derivatives of cholesterol. LXRB takes part in cholesterol， lipid， and carbohydrate metabolism. LXRB responds to increasing cholesterol levels via transactivation of genes involved in sterol transport （ABCA1， ABCG1， ABCG5， and ABCG8）， cholesterol efflux and high-density lipoprotein （HDL） metabolism， and sterol catabolism （CYP7A1）. NR1H2 is involved in regulating cellular lipid content through activation of SREBP-1c， which is the principal regulator of de novo lipogenesis. LXRB upregulates angiopoietin like protein 3 （Angpf13）， part of the family of VEGFs that is also a main regulator of lipid metabolism.
