SUB1 is a coactivator that functions together with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 interacts with the activation domain of transcription factor IIA （TFIIA） and TATA-binding protein （TBP）-associated factors （TAFs） to directly bind to double stranded DNA. SUB1 induces both activation and repression of RNAPII basal transcription， depending on the presence or absence of these transcription factors and holoenzyme components.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. SUB1 Human solution containing 20mM Tris HCL pH-8， 0.2M NaCl， 5mM DTT & 20% glycerol.
保存建议
SUB1 Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
