DKK1 is part of the dickkopf family. DKK1 is a secreted protein with 2 cysteine rich regions and takes part in embryonic development through its inhibition of the WNT signaling pathway. High levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is significantly involved in the development of tau phosphorylation. DKK1 reduces the differentiation of osteoblastic precursor cells. DKK1 is an important member in multiple myeloma bone disease. DKK1 expression is reduced in human colon tumors， implying that DKK-1 plays a role as a tumor suppressor gene in this neoplasia； the Wnt/beta-catenin pathway is downregulated by the induction of DKK1 expression， a mechanism that is missing in colon cancer.
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来源宿主
HEK293人胚肾上皮细胞中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The DKK1 protein was lyophilized from a 0.2um filtered solution containing no additives or preservatives. It is recommended to reconstitute the lyophilized DKK1 in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized DKK1 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution DKK1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
