NCS1 is part of the neuronal calcium sensor gene family， which encode calcium-binding proteins expressed primarily in neurons. NCS1 regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. NCS1 is related with secretory granules and modulates synaptic transmission and synaptic plasticity. NCS1 regulates GRK1 and substitutes for calmodulin. NCS1 stimulates PI4KB kinase activity and participates in long-term synaptic plasticity through its interaction with PICK1. NCS1 takes part in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear colorless solution. The NCS1 solution contains 20mM Tris-HCl pH-8， 1mM DTT， and 10% glycerol.
保存建议
NCS1 Recombinant Human although stable at 4℃ for 30 days， should be stored desiccated below -20℃ for periods greater than 30 days. Please avoid freeze-thaw cycles.
