FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain， FADD is recruited by TNFRSF6/Fas-receptor， tumor necrosis factor receptor， TNFRSF25， and TNFSF10/TRAIL-receptor， and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of， which allows it to recruit caspase-8， and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization， protein phosphorylation， and inhibitory molecules.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The FADD protein solution contains 20mM Tris-HCl， pH-8， and 10% glycerol.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
