VPS28 is a subunit of the ESCRT-I complex （endosomal complexes required for transport） involved in the sorting of ubiquitinated proteins. VPS28 is involved in endosomal sorting of cell surface receptors using a multivesicular body/late endosome pathway. VSP28 binding with the TSG101 may have significant roles in budding of Retroviruses， such as HIV-1 and Ebola virus.
VSP28 interacts with TSG101， VPS37B， VPS37C， FAM125A and FAM125B， and also with VPS36， this interaction mediates the association with the ESCRT-II complex. Furthermore it interacts with SNF8 and VPS25 and CEP55.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The VPS28 protein solution contains 20mM Tris-HCl buffer （pH 7.5）， 1mM DTT and 10% Glycerol.
保存建议
VPS28 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
