TCL1A （T-cell leukemia/lymphoma 1A） is a protein with a possible role in intracellular regulation of T cell signaling. TCL1A enhances cell proliferation， stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A is restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. TCL1A is preferentially expressed early in T and B-lymphocyte differentiation. Chromosomal anomalies activating TCL1A are found in chronic T-cell leukemias （T-CLL）.
TCL1A enhances the phosphorylation and activation of AKT1， AKT2 and AKT3. TCL1A promotes nuclear translocation of AKT1. TCL1A binds to the pleckstrin homology domain of Akt （protein kinase B） family proteins， which facilitates Akt dimerization and activity. By increasing Akt activity， TCL1A can enhance the serine/threonine phosphorylation of major Akt signaling substrates， for example Ikk complex， mTOR， BAD， p70S6 kinase， FOXO transcription factors and GSK3b. These substrates regulate cellular differentiation， growth， survival， and metabolism.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The TCL1A protein solution contains 50mM Tris-HCl buffer （pH7.5） and 10% glycerol.
保存建议
TCL1A although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
