CRABP1 is a member of special carrier proteins for members of the vitamin A family. It is believed that CRABP1 has an essential role in retinoic acid-mediated differentiation and proliferation processes. Though， CRABP1 is structurally similar to the cellular retinol-binding proteins， it binds only retinoic acid at specific sites within the nucleus， which may contribute to vitamin A-directed differentiation in epithelial tissue. CRABP1 is constitutively expressed and is thought to have different functions in the cell than the related CRABP2. CRABP1 forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.
Loss of CRABP1 function as a result of hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma. Furthermore， frequent methylation-associated silencing of CRABP1 is linked to esophageal squamous-cell carcinoma.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The CRABP1 protein solution contains 20mM Tris-HCl buffer （pH8.0） and 10% glycerol.
保存建议
CRABP1 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
