Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic， such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers， and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells.
Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The protein contains 10mM Tris-HCL pH-8， 1mM EDTA and 250mM NaCl. Suspend BclXL in 100?l of 0.5M Acetic acid， over night at 4°C.
Dilute 10 fold into selected buffer system.
Bcl-XL has tendency to form intramolecular disulfide bond， 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel， 10mM DTT is recommended.
保存建议
Lyophilized Bcl-XL although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Bcl-XL should be stored at 4℃ between 2-7 days and for future use below
-18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
