DDIT3 reduces DNA-binding activity of C/EBP and lap by forming heterodimers which don’t bind DNA. DDIT3， also known as GADD153， is a basic domain-leucine zipper（bZIP） transcription factor of C/EBP family. DDIT3 protein is up-regulated by several stresses， such as amino acid or glucose starvation， endoplasmic reticulum （ER） stress， osmotic stress and hypoxia. DDIT3 protein is invloved in ER stress-mediated apoptosis and in disease including diabetes， brain ischemia and neurodegenerative disease. DDIT3 plays a role in asoprisnil-induced apoptosis. Hypoglycaemia-induced necrotic cell death of neuroblastoma cells is an active process mediated via the induction of the transcription factor DDIT3. DDIT3 plays an important role in melanoma progression. HRG stimulation of mammary epithelial cells induces the expression of DDIT3 mRNA and protein and transcription of DDIT3 promoter.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered colorless solution. The DDIT3 protein solution （1mg/ml） contains 20mM Tris-HCl pH-8 and 20% glycerol.
保存建议
DDIT3 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
