STIM1 is a type-1 transmembrane protein that is necessary for store-operated Ca（2+） entry， a process of extracellular Ca（2+） influx in response to the depletion of Ca（2+） stores in the endoplasmic reticulum （ER）. STIM1 localizes predominantly to the ER； upon Ca（2+） release from the ER， STIM1 translocates to the ER-plasma membrane junctions and activates Ca（2+） channels. STIM1 is an adhesion molecule involved in early hematopoiesis by mediating attachment to stromal cells. STIM1 controls the survival and/or proliferation of b-cell precursors. STIM1 gene is one of several genes located in the imprinted gene domain of 11p15.5， a significant tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome， Wilms tumor， rhabdomyosarcoma， adrenocrotical carcinoma， and lung， ovarian， and breast cancer. STIM1 is involved in malignancies as well as early hematopoiesis， by mediating attachment to stromal cells. STIM1 is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene （RRM1）， with the 3’ end of this gene situated 1.6 kb from the 5’ end of the RRM1 gene.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The STIM1 protein solution （1mg/ml） contains 20mM Tris pH-7.5.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
