Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor with a molecular weight of about 67，000 derived from human urine which inhibits the activity of trypsin， chymotrypsin， lactate， lipase， hyaluronidase and various pancreatic enzymes. Ulinastatin is effective for acute pancreatitis， chronic recurrent pancreatitis and hemorrhagic， traumatic and endotoxic shocks. Ulinastatin is has strong inhibition effect to various protease， sugar and fat hydrolase. Ulinastatin precursor is proteolytically processed into distinct functioning proteins. urinary trypsin inhibitor belongs to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. Uristatin gene is located on chromosome 9 in a cluster of lipocalin genes.
High levels of Ulinastatin secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane.
Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma.
Ulinastatin particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte.
序列
请咨询我们客服或者请查看品牌官方网站
来源宿主
毕赤酵母中重组表达
溶解建议
Sterile Filtered solution. Formulated in 1X PBS.
保存建议
Ulinastatin although stable at 15℃ for 2 weeks， should be stored desiccated below -18℃.
Please prevent freeze-thaw cycles.
