Complement C4c is a degradation product of C4b which is cleaved by C4b/C3b inactivator to yield C4d and C4c.
Complement C4c interacts with C1 and C2 to form C3 convertase of the classic activation pathway. Systemic lupus erythematosus （SLE） is often associated with congenital C4 deficiency. Reduced levels of components of the classic pathway （C1， C2， C4， C3） are common after such activation， e.g. in SLE， acute serum sickness and conditions associated with circulating immune complexes.
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人血浆中提取纯化
溶解建议
Sterile Filtered clear solution. The Human Complement C4c solution is in Sodium Phosphate buffer pH 7.0 containing 0.15M NaCl and 0.09% NaN3.
保存建议
Human C4c although stable at 4℃ for 1 week， should be stored at
-15℃.
Please avoid freeze-thaw cycles.
