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中文名称

【因子VIII RA】重组人凝血因子VIII相关抗原

英文名字
Recombinant Human Melanoma Antigen Family A, 3
供应商
ProSpec
产品货号
PRO-502
产品报价
¥询价/10ug   ¥1mg   ¥2ug
产品说明书
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产品新闻
背景资料
Factor VIII related antigen or von Willebrand factor is a multimeric glycoprotein. It has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. As not all endothelial cells synthesize / store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant. Staining for factor VIII related antigen has also been used to measure angiogenesis, an indicator of tumor recurrence. vWF functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. vWF is critical to the hemostasis process. vWF is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde’s syndrome, and possibly hemolytic-uremic syndrome.
vWF is produced constitutively in the endothelium (in the Weibel-Palade bodies), in the megakaryocytes (?-granules of platelets), and in the subendothelial connective tissue. Since Von Willebrand factor is not an enzyme it has no catalytic activity. vWF’s principal function is binding to other proteins, mainly to Factor VIII and it is essential in platelet adhesion to wound sites. Factor VIII is attached to vWF while inactive in the circulation. Factor VIII degrades quickly when not attached to vWF.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. Factor VIII Related Antigen in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
保存建议
Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
其他
ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司,具有20多年的生产经验,专注于蛋白(重组及合成)生产研发。我们的核心产品包括:干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
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