Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors， including clear cell renal carcinomas， pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor， and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in b sheet （b-domain） and a smaller a-helical domain （a-domain）， held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor （HIF）.
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大肠杆菌中重组表达
溶解建议
Sterile filtered colorless solution. The Von Hippel-Lindau Protein contains 1x PBS pH-7.4， 2mM EDTA， and 1mM DTT.
保存建议
Store at 4℃ if entire vial will be used within 2-4 weeks.
Store， frozen at -20℃ for longer periods of time.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Avoid multiple freeze-thaw cycles.
