Recombinant Human PEX （C-terminal hemopexin-like domain of MMP-2） is a noncatalytic Metalloproteinase Fragment with Integrin Binding Activity and can inhibit cell associated collagenolytic activity both in vitro and in vivo.
Moreover， PEX can block angiogenesis and tumor growth in vivo， providing a potentially novel therapeutic approach for diseases associated with neovascularization. The appearance of PEX at sites of neovascularization may not only control normal angiogenesis， but when administered in sufficient quantities， may provide a naturally-occurring therapeutic inhibitor of diseases associated with angiogenesis. PEX mediates interaction with inhibitors and the cell surface， and is vital for activation. PEX is composed of 4 sub-domains arranged as a 4-bladed propeller.
PEX， which interferes with the cell membrane activation of MMP-2， reduced Rac1- promoted cell invasiveness as observed by collagen invasion assay. It has also been described that PEX prevents binding of MMP-2 to the integrin avb3.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The protein was lyophilized with 2mM Tris pH-7.4. It is recommended to reconstitute the PEX in sterile 18MΩ-cm H2O not less than 100ug/ml， which can then be further diluted to other aqueous solutions.
保存建议
Lyophilized PEX although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution PEX should be stored at 4℃ between 2-7 days and for future use below
-18℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
