TRIM21 is a member of the tripartite motif （TRIM） family. The TRIM motif includes three zinc-binding domains， a RING， a B-box type 1 and a B-box type 2， and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein， which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells， and tissue specific differences in Ro/SSA proteins were identified.
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来源宿主
大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. The protein solution contains 6M Urea， 500mM NaCl and 10mM Tris pH8.0.
保存建议
Lyophilized RO-52 although stable at 4℃ for 3 weeks， should be stored desiccated below -18℃.
Please prevent freeze-thaw cycles.
