Troponin is a fundamental regulatory protein of striated muscle contraction， and together with tropomyosin， is positioned on the actin filament. Troponin has 3 subunits: TnI- the inhibitor of actomyosin ATPase； TnT- contains the binding site for tropomyosin； and TnC- the protein encoded by the TNNC1 gene. The binding of calcium to TnC stops the inhibitory action of TnI， consequently allowing the interaction of actin with myosin， the hydrolysis of ATP， and the generation of tension. Mutations in the TNNC1 gene are linked to cardiomyopathy dilated type 1Z.
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大肠杆菌中重组表达
溶解建议
Sterile Filtered clear solution. The protein solution contains 150mM NaCl， 10mM sodium phosphate， 0.05% NaN3， pH 7.0.
保存建议
TNC although stable at room temperature for 3 weeks， should be stored at 4℃.
For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.
Please prevent freeze-thaw cycles.
