Coagulation factor VIII participates in the intrinsic pathway of blood coagulation； factor VIII is a cofactor for factor IXa which， in the presence of Ca+2 and phospholipids， converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein， isoform a， which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein， isoform b， which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A， a common recessive X-linked coagulation disorder.
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来源宿主
人血浆中提取纯化
溶解建议
Sterile Filtered White lyophilized （freeze-dried） powder. The lyophilized protein 200IU/ml was lyophilized from a sterile solution containing 1.5% Glycine， 160mM Calcium chloride and 25mM NaCitrate and 25mM NaCl. It is recommended to reconstitute the lyophilized Factor-VIII in sterile 18MΩ-cm H2O at a concentration of 200IU/ml， which can then be further diluted to other aqueous solutions.
Make sure that the vial has reached room temperature prior to its reconstitution， otherwise it might precipitate.
保存建议
Lyophilized Factor-VIII although stable at room temperature for 1 week， should be stored desiccated between 2-8℃. Upon reconstitution Factor-VIII should be storedat 4℃.
