Small nuclear ribonucleoprotein polypeptide G （SNRPG） is a member of the snRNP Sm proteins family. There are at least 7 isoforms， B/B， E， F， G， D1， D2， and D3. This class of common proteins has a vital role in the biogenesis of the snRNPs. The human Sm G genes are mapped to chromosomes 2. Furthermore， these proteins represent the major targets for the supposed anti-Sm auto-antibodies which are diagnostic for SLE （systemic lupus erythematosus）. One class of these autoantibodies reacts specifically with native Sm E-F-G complexes.
