Dickkopf-related protein 1 （DKK1） antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by creating a ternary complex with the transmembrane protein KREMEN which promotes internalization of LRP5/6. DKKs have a significant role in vertebrate development， where they locally inhibit Wnt controlled processes for instance antero-posterior axial patterning， limb development， somitogenesis and eye formation. Furthermore， Dkks are involved in bone formation and bone disease， cancer and Alzheimer disease in Adults.
