Kirsten Rat Sarcoma Viral Oncogene， Isoform 2A （KRAS-2A） belongs to the small GTPase superfamily. The KRAS-2A protein is involved in a variety of malignancies， including lung adenocarcinoma， mucinous adenoma， ductal carcinoma of the pancreas and colorectal carcinoma. Ras family members impact cell growth and differentiation events in a subcellular membrane compartmentalization-based signaling system under normal conditions. Oncogenic Ras can deregulate processes which control both cell proliferation and apoptosis.
