Activity-regulated cytoskeleton-associated protein （ARC） takes part in the regulation of cell morphology and cytoskeletal organization and is required for consolidation of synaptic plasticity as well as formation of long-term memory. ARC regulates endocytosis of AMPA receptors in response to synaptic activity and is also required for homeostatic synaptic scaling of AMPA receptors. ARC is required in the stress fiber dynamics and cell migration.
