Sarcoglycan Delta （SGCD） is one of the four known components of the sarcoglycan complex， which is a subcomplex of the dystrophin-glycoprotein complex （DGC） and is expressed mainly in skeletal and cardiac muscle. DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. SGCD protein’s mutations have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. SGCD gene expression is regulated by MITF In melanocytic cells.
