ABI gene family member 3 （ABI3） is a member of the ABI family. Members of the ABI family encode proteins which contain a homeobox homology domain， proline rich region and Src-homology 3 （SH3） domain. Abi family members are assumed to negatively regulate cell growth and transformation， including cellular transformation through v-Abl as well controlling as mediate cell motility by regulating actin polymerization in lamellipodia and filopodia. ABI3 impedes ectopic metastasis of tumor cells as well as cell migration， which is accomplished through interaction with p21-activated kinase.
