NHP2 belongs to the H/ACA snoRNPs （small nucleolar ribonucleoproteins） gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 （NOLA2） forms a small ribonucleoprotein particle with GAR1 （NOLA1）， Nop10 for the isomerization of uridine to pseudouridine. NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies.
