TP53-induced glycolysis and apoptosis regulator （TIGAR or C12ORF5）， is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to protect against oxidative stress. C12ORF5 specifically functions to block glycolysis， leading the pathway to the pentose phosphate shunt and decreasing the intracellular concentration of reactive oxygen species. Therefore， it is thought that C12ORF5 may act to modulate the apoptotic response to p53， thus allowing cells to survive mild or transient stresses.
