SNRPF is a member of the snRNP Sm proteins family. There are at least seven isoforms， E， F， G， D1， D2， D3 and B/B. This type of common proteins have a crucial part in the biogenesis of the snRNPs. Moreover， they represent the major targets for the so-called anti-Sm auto-antibodies that are diagnostic for systemic lupus erythematosus （SLE）. SNRPF assist in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.
