中文名称

重组人多配体聚糖-4（rHuSDC—4）

英文名字

Recombinant Human Syndecan-4 (rHuSDC-4)

供应商

Bioworld

产品货号

PR1117

产品报价

￥询价/10ug

产品说明书

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产品新闻

背景资料

Syndecan-4 also known as amphiglycan or ryudocan, is a member of the syndecan family of Type 1 transmembrane proteins capable of carrying heparan sulfate (HS) and chondroitin sulfate glycosaminoglycans. The four vertebrate syndecans have two conserved cytoplasmic domains and divergent extracellular portions, except for HS attachment sites. Syndecan4 is the most similar to Syndecan2, but is more universally expressed and is found in virtually every cell type. Expression can be upregulated by TGFβ2 and in response to mechanical stress in smooth muscle, wound healing, arterial injury or acute myocardial infarction, probably in response to at least one inflammatory mediator. Human Syndecan4 ECD shares approximately 79%, 78% and 81% aa identity with mouse, rat and porcine Syndecan4 ECD, respectively. Addition of 20 80 disaccharides per side chain adds considerably to the size of the 20 kDa core protein. Noncovalent homodimerization of Syndecan4 is dependent on the transmembrane domain. The HS chains can bind fibronectin, SDF1, antithrombin, FGF2, midkine and tissue factor pathway inhibitor and can present FGF2 to its receptors. Proteolytic cleavage by plasmin, thrombin or a metalloproteinase may create a functional ectodomain. Genetic disruption of the Syndecan4 gene causes a mild phenotype, presumably due to compensation by other syndecans, but mice have an increase in placental thrombi as well as defects in wound healing and response to endotoxin shock.

序列

MASSIRETEV IDPQDLLEGR YFSGALPDDE DVVGPGQESD DFELSGSGDL DDLEDSMIGP EVVHPLVPLD NHIPERAGSG SQVPTEPKKL EKNEVIPKRI SPVEESEDVS NKVSMSSTVQ GSNIFERTEV LALEHHHHHH

来源宿主

Escherichia coli.

溶解建议

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20

保存建议

This lyophilized preparation is stable at 2-8

其他

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注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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