The protein is located in both the ER and cis-Golgi compartments from biochemical and immunofluorescence studies.UBXD4 as one of the cytosolic proteins that interact directly with the α3 and α4 nAChR subunits.Overexpression of UBXD4 in differentiated PC12 cells (dPC12) increased nAChR cell surface expression, especially that of the α3β2 subtype.
