PGK1 is an X-linked enzyme that has a major role in the glycolytic pathway. PGK1 is a glycolytic enzyme which catalyzes the conversion of 1，3-diphosphoglycerate to 3-phosphoglycerate， generating an ATP molecule. PGK1 may also act as a cofactor for polymerase alpha. Defects in the PGK1 gene are usually associated with chronic hemolytic anemia， though it can be accompanied by either mental retardation or muscular disease （rhabdomyolysis）. Overexpression of PGK1 and its signalling targets are possibly an expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination. It was shown that PGK1 is differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人磷酸甘油酸激酶（PGK1）产品为过滤灭菌的无色溶液；其中人磷酸甘油酸激酶（PGK1）产品溶解于20mM Tris （pH 8.0），10%甘油，1mM DTT溶液中.
