CDK8 （cyclin-dependent kinase 8； protein kinase K35； CDK8 protein kinase； cell division protein kinase 8； K35） is a member of the cyclin-dependent protein kinase （CDK） family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28， and Schizosaccharomyces pombe cdc2， and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex， which phosphorylates the carboxy-terminal domain （CTD） of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH （TFIIH）， thus providing a link between the ’Mediator-like’ protein complexes and the basal transcription machinery.
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大肠杆菌中重组表达
溶解建议
提供的人细胞周期蛋白依赖激酶8（CDK8）产品为溶液形式；其中0.1mg/ml人细胞周期蛋白依赖激酶8（CDK8）产品溶解于25 mM HEPES，pH 7.9，125mM KCI，0.5% TX-100，50%甘油溶液中.
