The 14-3-3 family of proteins plays a key regulatory role in signal transduction， checkpoint control， apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms， ?， ?， ?， ?， ?， ? and ? that have been identified in mammals. The 14-3-3gamma， a subtype of the 14-3-3 family of proteins， was thought to be brain and neuron-specific. It has been shown to interact with RAF1 and protein kinase C， proteins involved in various signal transduction pathways.
