The Casein kinase 2 （EC2.7.11.1） is a serine/threonine-selective protein kinasethat is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cyclecontrol， DNA repair， regulation of the circadian rhythmand other cellular processes.
Casein kinase 2 activity has been reported to be activated following Wnt signaling pathwayactivation. A Pertussis toxin-sensitive G proteinand Disheveled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.
Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人酪蛋白激酶2a，His标签（CSNK2A1 His）产品为过滤灭菌的透明溶液；其中人酪蛋白激酶2a，His标签（CSNK2A1 His）产品溶解于20mM Tris pH 8.0 ，500mM NaCl，1mM DTT，50%甘油溶液中.
