中文名称

CD319重组蛋白

英文名字

CD319 Recombinant Protein

供应商

Bioworld

产品货号

NCP0319

产品报价

￥询价/500ug

产品说明书

点击查看

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系400-6800-868

产品新闻

背景资料

CRACC/SLAMF7/CD319 (also known as CS1) is a member of the signaling lymphocytic activation molecule (SLAM) family. It is a single-pass type l transmembrane glycoprotein expressed on NK cells, subsets of mature dendritic cells, activated B and T lymphocytes, but not in promyelocytic B or T cell lines. Expression of this protein has been detected in the spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea. Homophilic interactions of CRACC/SLAMF7/CD319 modulate the activity and differentiation of immune cells. CRACC/SLAMF7/CD319 may function as an inhibitory or activating receptor in immune cells depending on cellular context and availability of adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. In the presence of SH2D1B/EAT-2, CRACC/SLAMF7/CD319 activates NK cells and B cells. T cells lack SH2D1B/EAT-2 expression, and therefore CRACC/SLAMF7/CD319 acts as an inhibitory receptor. In LPS-activated monocytes, CRACC/SLAMF7/CD319 negatively regulates production of proinflammatory cytokines. CRACC/SLAMF7/CD319 is upregulated in multiple myeloma and is implicated in the uncontrolled proliferation of these cells, and thus has become the target for therapeutic intervention. Seven isoforms of CRACC/SLAMF7/CD319 produced by alternative splicing have been identified.

序列

因CD319重组蛋白/CD319 Recombinant Protein产品的序列过长，详情查看产品说明书

来源宿主

E.coli

溶解建议

PBS, 4M Urea, PH7.4

保存建议

Store at 4

其他

Bioworld是专一服务于生命科学研究的专业技术型企业，Bioworld品牌创立以来拥有10000多种常规产品现货，现有8000多种现货抗体，以及其他IVD原料，蛋白等现货产品。在细胞信号通路、免疫学、蛋白组学上拥有显著优势，其抗体产品、生长因子、IVD原料等为生命科学科研工作者提供了极大的便利

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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